Since the late 1980s, the human genetics and genomics research community has been promising to usher in a “new paradigm for health care”—one that uses molecular profiling to identify human genetic variants implicated in multifactorial health risks. After the completion of the Human Genome Project in 2003, a wide range of stakeholders became committed to this “paradigm shift,” creating a confluence of investment, advocacy, and enthusiasm that bears all the marks of a “scientific/intellectual social movement” within biomedicine. Proponents of this (...) movement usually offer four ways in which their approach to medical diagnosis and health care improves upon current practices, arguing that it is more “personalized,” “predictive,” “preventive,” and “participatory” than the medical status quo. Initially, it was personalization that seemed to best sum up the movement's appeal. By 2012, however, powerful opinion leaders were abandoning “personalized medicine” in favor of a new label: “precision medicine.” The new label received a decisive seal of approval when, in January 2015, President Obama unveiled plans for a national “precision medicine initiative” to promote the development and use of genomic tools in health care. (shrink)

In 820 the corrections of Buecheler and Scaliger are accepted. In 822 the MSS. have quom penes me potestas; quom for quos from v. 823, lacuna supplied by Klotz, met , by Leo, mei . I conceive an intermediate stage: quom penes mei potestas, which would account for the lacuna by haplography, as well as for the change of mei to me.

This instalment of suggestions is put forward with all the diffidence one is bound to feel after an examination of the great body of the manuscripts. No great writer's text has hung upon a more slender thread of evidence. Larger matters than verbal emendation are touched upon in the discussion of poem LXVIII. My theory of how our texts became dislocated , and some new light I hope to throw upon the form and meaning of the Peleus and Thetis, must (...) be withheld until a later occasion. (shrink)

Miss Gertrude Hirst's article on Aeneid VII.in the April number, 1916, of the C.Q. depends for its cogency upon dates in Propertius. Not wishing that her careful work should be vitiated by premisses which may shortly be proved false, I venture to set out the bare results of my own researches in this field of dates, results which have stood the test of several years of further examination.

I Purpose in this essay to declare by means of a few chosen examples the theory and method upon which I have for over twelve years been proceeding to the restoration of the text of Propertius. I had always hoped to present my results first in their final form; but the long delays and the immediate circumstance of war compel me to a partial presentation of what is now in all essentials a finished work. The examples I choose are mostly (...) those which I used in 1911 in a paper read before the Philological Societies of Cambridge and Oxford; nothing but detail has been changed in any part of my theory since that date. (shrink)

A. I begin with some emendations founded on familiar evidence. ii. 9. aspice quos summittat humus formosa colores.In each of the following verses of the stanza from u. 9 to u. 14 natural and spontaneous beauty is the subject. Verse 9 has seemed unsatisfactory because it lacks the very point which it should introduce. All the emendations have attacked formosa because it is repeated in u. 11: morosa, Housman, dumosa, nemorosa, muscosa, and other even less probable adjectives have been suggested.

A. I begin with some emendations founded on familiar evidence. ii. 9. aspice quos summittat humus formosa colores. In each of the following verses of the stanza from u. 9 to u. 14 natural and spontaneous beauty is the subject . Verse 9 has seemed unsatisfactory because it lacks the very point which it should introduce. All the emendations have attacked formosa because it is repeated in u. 11: morosa, Housman , dumosa, nemorosa, muscosa, and other even less probable adjectives (...) have been suggested. (shrink)

Too late for my edition of Propertius, but in time, I hope, to anticipate one criticism of the many that will be aimed at its details, I have detected a serious flaw in my text of his elegy upon Vertumnus . It is not so serious as some of the flaws caused in it by the corruption of our archetype; but instead of helping I have hindered truth in respect of two of the couplets. Now I should like to put (...) forward a correction, which seems to set us in a fair way to recover the authors's pattern, as well as his words, in the second half of the elegy. (shrink)

Moral leadership matters. As world politics enters a new and dangerous era, judgment, constancy, moral purpose, and a willingness to overcome partisan politicking are essential for America's leaders. Tempered Strength finds the alternative standard of leadership that Americans are seeking in the classical philosophy of prudence. Ethan Fishman's new work brings together leading American political scientists—including Ronald Beiner, Kenneth L. Deutsch, and George Anastaplo—to discuss the evolution of a standard of prudential leadership both reasonable in nature and practical in (...) scope. Section One studies the meaning of prudence and its evolution in the history of political science from Aristotelian phronesis to Xenophon, Thomas Aquinas, Edmund Burke, and Michael Oakeshott. Section Two demonstrates how the theory of prudential leadership can be applied to practical political issues. (shrink)

_The purpose_ of the article is to clarify the philosophical principle of the local in the context of modern political governance. _The theoretical basis_ of the research embraces scenario analysis, dialectical and existential approaches, as well as philosophical anthropology and philosophy of communication. Local communities are a specific reflection of the connection between a person and a place. The specifics of the formation of a special mode of being, which forms and reproduces relations of loyalty, mutual understanding, and a common (...) feeling in the locus, are established. _Originality._ The article for the first time focuses on the anthropological content of local existence, which is the matrix of civil culture and the prospects of its integration into the global cultural space. _Conclusions._ Local identity as an object of purposeful formation in the conditions of nation-building requires considering the philosophical provisions that were introduced in the anthropological discourse. At the current stage, Ukrainian civil culture strives to invent specific local meanings of political identity in the conditions of external aggression. Its main components will be consensus, mutual respect, integrity, and the will to unite in order to protect statehood. Interdisciplinary meanings of locality form subject-object relations within which modern political management should be carried out. Taking into account the ethnic, cultural, and socio-functional, and role aspects of locality promises to ensure effective decision-making and increase the well-being of modern local communities. The political context of locality is formed based on the interaction of local political actors and institutions. Their examination within the framework of the case studies approach allows for empirically substantiating the local priorities of political actions. It also indicates the specific functionality of local political and administrative structures. at the local level, the discussed source of locality is the question of the origin or authenticity of the local population. For political governance, this is one of the meaningful contexts for justifying local autonomy or even sovereignty. (shrink)

Open peer commentary on the article “Circularity and the Micro-Macro-Difference” by Manfred Füllsack. Upshot: We join Füllsack in his effort to untangle the concepts of circular causation, macro states, and observation by reanalyzing one of our own simulations in the light of these concepts. This simulation presents an example agent that keeps track of its own macro states. We examine how human observers can consider such an agent as an observing agent on its own.

Open peer commentary on the article “Subsystem Formation Driven by Double Contingency” by Bernd Porr & Paolo Di Prodi. Upshot: Agents that learn from perturbations of closed control loops are considered constructivist by virtue of the fact that their input (the perturbation) does not convey ontological information about the environment. That is, they learn by actively experiencing their environment through interaction, as opposed to learning by registering directly input data characterizing the environment. Generalizing this idea, the notion of learning by (...) experiencing provides a broader conceptual framework than cybernetic control theory for studying the double contingency problem, and may yield more progress in constructivist agent design. (shrink)

Open peer commentary on the article “Exploration of the Functional Properties of Interaction: Computer Models and Pointers for Theory” by Etienne B. Roesch, Matthew Spencer, Slawomir J. Nasuto, Thomas Tanay & J. Mark Bishop. Upshot: We support Roesch and his co-authors’ theoretical stance on constructivist artificial agents, and wish to enrich their “exploration of the functional properties of interaction” with complementary results. By revisiting their experiments with an agent that we developed previously, we explore two issues that they deliberately left (...) aside: autonomous intentionality and dynamic reutilization of knowledge by the agent. Our results reveal an alternative pathway to constructivism that addresses the central question of intentionality in a single agent from the very beginning of its design, suggesting that the property of distributed processing proposed by Roesch et al. is not essential to constructivism. (shrink)